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Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity

Maintaining stemness of leukemic stem cells (LSCs) and reciprocal interactions between leukemia and stromal cells support leukemic progression and resistance to chemotherapy. Targeting the niche-based microenvironment is thus a new approach for leukemia therapy. Cordycepin is an analogue of adenosin...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Liang, Shu-Man, Lu, Yi-Jhu, Ko, Bor-Sheng, Jan, Yee-Jee, Shyue, Song-Kun, Yet, Shaw-Fang, Liou, Jun-Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339716/
https://ncbi.nlm.nih.gov/pubmed/28266575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43930
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