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Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity

Maintaining stemness of leukemic stem cells (LSCs) and reciprocal interactions between leukemia and stromal cells support leukemic progression and resistance to chemotherapy. Targeting the niche-based microenvironment is thus a new approach for leukemia therapy. Cordycepin is an analogue of adenosin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Liang, Shu-Man, Lu, Yi-Jhu, Ko, Bor-Sheng, Jan, Yee-Jee, Shyue, Song-Kun, Yet, Shaw-Fang, Liou, Jun-Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339716/
https://ncbi.nlm.nih.gov/pubmed/28266575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43930
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