CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis

CCN1, an extracellular protein also known as cysteine-rich protein 61 (Cyr61), is a novel pro-inflammatory factor involved in the pathogenesis of rheumatoid arthritis. As an inflammatory disease, psoriasis is characterized by keratinocyte activation-induced epidermal hyperplasia and cytokine-mediate...

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Publicat a:Sci Rep
Autors principals: Sun, Yue, Zhang, Jie, Zhai, Tianhang, Li, Huidan, Li, Haichuan, Huo, Rongfen, Shen, Baihua, Wang, Beiqing, Chen, Xiangdong, Li, Ningli, Teng, Jialin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339692/
https://ncbi.nlm.nih.gov/pubmed/28266627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43310
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