Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex

Disruption of myelination during development has been implicated in a range of neurodevelopmental disorders including tuberous sclerosis complex (TSC). TSC patients with autism display impairments in white matter integrity. Similarly, mice lacking neuronal Tsc1 have a hypomyelination phenotype. Howe...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Ercan, Ebru, Han, Juliette M., Di Nardo, Alessia, Winden, Kellen, Han, Min-Joon, Hoyo, Leonie, Saffari, Afshin, Leask, Andrew, Geschwind, Daniel H., Sahin, Mustafa
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339668/
https://ncbi.nlm.nih.gov/pubmed/28183733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160446
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