Prototype Foamy Virus Envelope Glycoprotein Leader Peptide Processing Is Mediated by a Furin-Like Cellular Protease, but Cleavage Is Not Essential for Viral Infectivity

Analogous to cellular glycoproteins, viral envelope proteins contain N-terminal signal sequences responsible for targeting them to the secretory pathway. The prototype foamy virus (PFV) envelope (Env) shows a highly unusual biosynthesis. Its precursor protein has a type III membrane topology with bo...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Duda, Anja, Stange, Annett, Lüftenegger, Daniel, Stanke, Nicole, Westphal, Dana, Pietschmann, Thomas, Eastman, Scott W., Linial, Maxine L., Rethwilm, Axel, Lindemann, Dirk
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC533949/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15564494/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.24.13865-13870.2004
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