Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation

AIMS: Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA induces myelin vacuolation in axonal tracts. Here, we explore the nature, the time course, and the role of the complement system in this...

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Dettagli Bibliografici
Pubblicato in:Front Neurol
Autori principali: Granados-Durán, Pablo, López-Ávalos, María Dolores, Cifuentes, Manuel, Pérez-Martín, Margarita, Fernández-Arjona, María del Mar, Hughes, Timothy R., Johnson, Krista, Morgan, B. Paul, Fernández-Llebrez, Pedro, Grondona, Jesús M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339270/
https://ncbi.nlm.nih.gov/pubmed/28326060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2017.00078
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