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Early Involvement of Lysosome Dysfunction in the Degeneration of Cerebral Cortical Neurons Caused by the Lipid Peroxidation Product 4-Hydroxynonenal

Free radical–mediated oxidative damage to proteins, lipids and DNA occurs in neurons during acute brain injuries and in neurodegenerative disorders. Membrane lipid peroxidation contributes to neuronal dysfunction and death, in part by disrupting neuronal ion homeostasis and cellular bioenergetics. E...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Zhang, Shi, Eitan, Erez, Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339057/
https://ncbi.nlm.nih.gov/pubmed/28095639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13957
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