Mccrearamycins A–D, Geldanamycin-Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe

Four cyclopentenone-containing ansamycin polyketides (mccrearamycins A–D), and six new geldanamycins (Gdms B–G, including new linear and mycothiol conjugates), were characterized as metabolites of Streptomyces sp. AD-23-14 isolated from the Rock Creek underground coal mine acid drainage site. Biomim...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Wang, Xiachang, Zhang, Yinan, Ponomareva, Larissa V., Qiu, Qingchao, Woodcock, Ryan, Elshahawi, Sherif I., Chen, Xiabin, Zhou, Ziyuan, Hatcher, Bruce E., Hower, James C., Zhan, Chang-Guo, Parkin, Sean, Kharel, Madan K., Voss, S. Randal, Shaaban, Khaled A., Thorson, Jon S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339036/
https://ncbi.nlm.nih.gov/pubmed/28140487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201612447
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