Glycocalyx Restricts Adenoviral Vector Access to Apical Receptors Expressed on Respiratory Epithelium In Vitro and In Vivo: Role for Tethered Mucins as Barriers to Lumenal Infection

Inefficient adenoviral vector (AdV)-mediated gene transfer to the ciliated respiratory epithelium has hindered gene transfer strategies for the treatment of cystic fibrosis lung disease. In part, the inefficiency is due to an absence of the coxsackie B and adenovirus type 2 and 5 receptor (CAR) from...

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Autori principali: Stonebraker, Jaclyn R., Wagner, Danielle, Lefensty, Robert W., Burns, Kimberlie, Gendler, Sandra J., Bergelson, Jeffrey M., Boucher, Richard C., O'Neal, Wanda K., Pickles, Raymond J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC533903/
https://ncbi.nlm.nih.gov/pubmed/15564484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.24.13755-13768.2004
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