Effect of a small molecule Lipid II binder on bacterial cell wall stress

We have recently identified small molecule compounds that act as binders of Lipid II, an essential precursor of bacterial cell wall biosynthesis. Lipid II comprised a hydrophilic head group that includes a peptidoglycan subunit composed of N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNA...

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Udgivet i:Infect Drug Resist
Main Authors: Malin, Jakob, Shetty, Amol C, Daugherty, Sean C, de Leeuw, Erik PH
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2017
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338996/
https://ncbi.nlm.nih.gov/pubmed/28280373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S126254
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