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Effect of a small molecule Lipid II binder on bacterial cell wall stress

We have recently identified small molecule compounds that act as binders of Lipid II, an essential precursor of bacterial cell wall biosynthesis. Lipid II comprised a hydrophilic head group that includes a peptidoglycan subunit composed of N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNA...

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Detalhes bibliográficos
Publicado no:Infect Drug Resist
Main Authors: Malin, Jakob, Shetty, Amol C, Daugherty, Sean C, de Leeuw, Erik PH
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338996/
https://ncbi.nlm.nih.gov/pubmed/28280373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S126254
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