Pulmonary vascular collagen content, not cross-linking, contributes to right ventricular pulsatile afterload and overload in early pulmonary hypertension

Hypoxic pulmonary hypertension (HPH) is associated with pulmonary artery (PA) remodeling and right ventricular (RV) overload. We have previously uncovered collagen-mediated mechanisms of proximal PA stiffening in early HPH by manipulating collagen degradation and cross-linking using a transgenic mou...

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Publicado en:J Appl Physiol (1985)
Autores principales: Wang, Zhijie, Schreier, David A., Abid, Hinnah, Hacker, Timothy A., Chesler, Naomi C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338600/
https://ncbi.nlm.nih.gov/pubmed/27856711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00325.2016
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