TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies, depositions of insoluble α-synuclein, and other proteins that likely contribute to cellular toxicity and death during the disease. Gen...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Jinn, Sarah, Drolet, Robert E., Cramer, Paige E., Wong, Andus Hon-Kit, Toolan, Dawn M., Gretzula, Cheryl A., Voleti, Bhavya, Vassileva, Galya, Disa, Jyoti, Tadin-Strapps, Marija, Stone, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338534/
https://ncbi.nlm.nih.gov/pubmed/28193887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616332114
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