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Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments
Cardiac myosin binding protein C (cMyBP-C) has a key regulatory role in cardiac contraction, but the mechanism by which changes in phosphorylation of cMyBP-C accelerate cross-bridge kinetics remains unknown. In this study, we isolated thick filaments from the hearts of mice in which the three serine...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5338423/ https://ncbi.nlm.nih.gov/pubmed/28167762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614020114 |
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