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Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments

Cardiac myosin binding protein C (cMyBP-C) has a key regulatory role in cardiac contraction, but the mechanism by which changes in phosphorylation of cMyBP-C accelerate cross-bridge kinetics remains unknown. In this study, we isolated thick filaments from the hearts of mice in which the three serine...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kensler, Robert W., Craig, Roger, Moss, Richard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338423/
https://ncbi.nlm.nih.gov/pubmed/28167762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614020114
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