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Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes

Although cationic cell-penetrating peptides (CPPs) are able to bind to cell membranes, thus promoting cell internalization by active pathways, attachment of cargo molecules to CPPs invariably reduces their cellular uptake. We show here that CPP binding to lipid bilayers, a simple model of the cell m...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Weinberger, Andreas, Walter, Vivien, MacEwan, Sarah R., Schmatko, Tatiana, Muller, Pierre, Schroder, André P., Chilkoti, Ashutosh, Marques, Carlos M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338251/
https://ncbi.nlm.nih.gov/pubmed/28262825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43963
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