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WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance

Cisplatin is one of the most commonly used therapeutic drugs for cancer therapy, yet prolonged cisplatin treatment frequently results in drug resistance. To enhance therapeutic effect of cisplatin, we conducted a high throughput screening using a kinase library containing 704 kinases against triple...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zheng, Hongping, Shao, Fangyuan, Martin, Scots, Xu, Xiaoling, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338009/
https://ncbi.nlm.nih.gov/pubmed/28262781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43517
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