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Predicting the Remaining Lifespan and Cultivation-Related Loss of Osteogenic Capacity of Bone Marrow Multipotential Stromal Cells Applicable across a Broad Donor Age Range

Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed o...

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Publicado en:Stem Cells Int
Main Authors: Churchman, Sarah M., Boxall, Sally A., McGonagle, Dennis, Jones, Elena A.
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337353/
https://ncbi.nlm.nih.gov/pubmed/28298930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/6129596
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