Long-term passage of Vif-null HIV-1 in CD4(+) T cells expressing sub-lethal levels of APOBEC proteins fails to develop APOBEC resistance

APOBEC3G (A3G) is a cytidine deaminase with potent antiviral activity that is antagonized by Vif. A3G is expressed in a cell type-specific manner and some semi-permissive cells, including A3.01, express A3G but fail to block replication of Vif-null HIV-1. Here we explored the semi-permissive nature...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Miyagi, Eri, Kao, Sandra, Fumitaka, Miyoshi, Buckler-White, Alicia, Plishka, Ron, Strebel, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337162/
https://ncbi.nlm.nih.gov/pubmed/28131088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.01.016
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