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Chymase-dependent production of angiotensin II: an old enzyme in old hearts

Age-dependent alteration of the renin-angiotensin system (RAS) and generation of angiotensin II (Ang II) are well documented. By contrast, RAS-independent generation of Ang II in aging and its responses to exercise have not been explored. To this end, we examined the effects of chymase, a secretory...

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Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: Froogh, Ghezal, Pinto, John T., Le, Yicong, Kandhi, Sharath, Aleligne, Yeabsra, Huang, An, Sun, Dong
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336578/
https://ncbi.nlm.nih.gov/pubmed/27815252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00534.2016
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