MicroRNA-146a Induces Lineage Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Plk2 Expression

OBJECTIVE: Lineage negative bone marrow cells (lin(−) BMCs) are enriched in endothelial progenitor cells (EPCs) and mediate vascular repair. Aging-associated senescence and apoptosis result in reduced number and functionality of lin(−) BMCs, impairing their pro-repair capacity. The molecular mechani...

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Dettagli Bibliografici
Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Deng, Shanming, Wang, Huilan, Jia, Chunling, Chu, Xianming, Ma, Qi, Wei, Jianqin, Chen, Emily, Zhu, Wei, Macon, Conrad J, Jayaweera, Dushyantha T, Dykxhoorn, Derek M, Dong, Chunming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336135/
https://ncbi.nlm.nih.gov/pubmed/27908889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308378
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