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Development of a Fluorescence-Based, Ultra High-Throughput Screening Platform for Nanoliter-Scale Cytochrome P450 Microarrays

Cytochrome P450 enzyme (CYP450s) assays are critical enzymes in early-stage lead discovery and optimization in drug development. Currently available fluorescence-based reaction assays provide a rapid and reliable method for monitoring CYP450 enzyme activity but are confined to medium-throughput well...

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Bibliografische gegevens
Gepubliceerd in:J Biomol Screen
Hoofdauteurs: Sukumaran, Sumitra M., Potsaid, Benjamin, Lee, Moo-yeal, Clark, Douglas S., Dordick, Jonathan S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333991/
https://ncbi.nlm.nih.gov/pubmed/19525490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057109336592
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