The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells

Oxadiazines are heterocyclic compounds containing N-N-O or N-N-C-O system within a six membered ring. These structures have been up to now exclusively prepared via organic synthesis. Here, we report the discovery of a natural oxadiazine nocuolin A (NoA) that has a unique structure based on 1,2,3-oxa...

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Vydáno v:PLoS One
Hlavní autoři: Voráčová, Kateřina, Hájek, Jan, Mareš, Jan, Urajová, Petra, Kuzma, Marek, Cheel, José, Villunger, Andreas, Kapuscik, Alexandra, Bally, Marcel, Novák, Petr, Kabeláč, Martin, Krumschnabel, Gerhard, Lukeš, Martin, Voloshko, Ludmila, Kopecký, Jiří, Hrouzek, Pavel
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333925/
https://ncbi.nlm.nih.gov/pubmed/28253280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172850
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