Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics

Copper is one of the metals described to bind the Parkinson disease-related protein α-synuclein (aSyn), and to promote its aggregation. Although histidine at position 50 in the aSyn sequence is one of the most studied copper-anchoring sites, its precise role in copper binding and aSyn aggregation is...

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Bibliografiske detaljer
Udgivet i:Commun Integr Biol
Main Authors: Villar-Piqué, Anna, Rossetti, Giulia, Ventura, Salvador, Carloni, Paolo, Fernández, Claudio O., Outeiro, Tiago Fleming
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
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Mini-Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333520/
https://ncbi.nlm.nih.gov/pubmed/28289488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420889.2016.1270484
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