IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting

Genetic evolution that occurs during cancer progression enables tumour heterogeneity, thereby fostering tumour adaptation, therapeutic resistance and metastatic potential. Immune responses are known to select (immunoedit) tumour cells displaying immunoevasive properties. Here we address the role of...

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Udgivet i:Nat Commun
Main Authors: Takeda, Kazuyoshi, Nakayama, Masafumi, Hayakawa, Yoshihiro, Kojima, Yuko, Ikeda, Hiroaki, Imai, Naoko, Ogasawara, Kouetsu, Okumura, Ko, Thomas, David M., Smyth, Mark J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333095/
https://ncbi.nlm.nih.gov/pubmed/28233863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14607
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