Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

O6-Methylguanine-DNA methyltransferase (MGMT; DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase, EC 2.1.1.63), a unique DNA repair protein present in most organisms, removes the carcinogenic and mutagenic adduct O6-alkylguanine from DNA by stoichiometrically accepting the alkyl group on a...

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Autores principales: Tano, K, Shiota, S, Collier, J, Foote, R S, Mitra, S
Formato: Artigo
Lenguaje:Inglês
Publicado: 1990
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC53330/
https://ncbi.nlm.nih.gov/pubmed/2405387
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