Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.
O6-Methylguanine-DNA methyltransferase (MGMT; DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase, EC 2.1.1.63), a unique DNA repair protein present in most organisms, removes the carcinogenic and mutagenic adduct O6-alkylguanine from DNA by stoichiometrically accepting the alkyl group on a...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1990
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53330/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2405387/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.2.686 |
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