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SAFE USE OF ANTI-CD154 MONOCLONAL ANTIBODY IN PIG ISLET XENOTRANSPLANTATION IN MONKEYS

BACKGROUND: Anti-CD154mAb is a powerful costimulation blockade agent that is efficacious in preventing rejection, even in xenogeneic settings. It has been used in the majority of successful long-term pig-to-nonhuman primate islet transplantation models. However, its clinical use was halted as a resu...

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Detalhes bibliográficos
Publicado no:Xenotransplantation
Main Authors: Bottino, Rita, Knoll, Michael F., Graeme-Wilson, Joshua, Klein, Edwin C., Ayares, David, Trucco, Massimo, Cooper, David K.C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332295/
https://ncbi.nlm.nih.gov/pubmed/28058735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12283
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