Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2

Transglutaminases (TGMs) catalyze Ca(2+)-dependent transamidation of proteins with specified roles in blood clotting (F13a) and in cornification (TGM1, TGM3). The ubiquitous TGM2 has well described enzymatic and non-enzymatic functions but in-spite of numerous studies its physiological function in h...

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Publicado en:PLoS One
Autores principales: Thangaraju, Kiruphagaran, Király, Róbert, Demény, Máté A., András Mótyán, János, Fuxreiter, Mónika, Fésüs, László
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332030/
https://ncbi.nlm.nih.gov/pubmed/28248968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172189
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