Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

BACKGROUND: Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, suggesting dysregulation of the innate immune response in autoimmunity. In this...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Farina, Antonella, Peruzzi, Giovanna, Lacconi, Valentina, Lenna, Stefania, Quarta, Silvia, Rosato, Edoardo, Vestri, Anna Rita, York, Michael, Dreyfus, David H., Faggioni, Alberto, Morrone, Stefania, Trojanowska, Maria, Farina, G. Alessandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331713/
https://ncbi.nlm.nih.gov/pubmed/28245863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1237-9
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