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Efficacy of Urtoxazumab (TMA-15 Humanized Monoclonal Antibody Specific for Shiga Toxin 2) Against Post-Diarrheal Neurological Sequelae Caused by Escherichia coli O157:H7 Infection in the Neonatal Gnotobiotic Piglet Model

Enterohemorrhagic Escherichia coli (EHEC) is the most common cause of hemorrhagic colitis and hemolytic uremic syndrome in human patients, with brain damage and dysfunction the main cause of acute death. We evaluated the efficacy of urtoxazumab (TMA-15, Teijin Pharma Limited), a humanized monoclonal...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Moxley, Rodney A., Francis, David H., Tamura, Mizuho, Marx, David B., Santiago-Mateo, Kristina, Zhao, Mojun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331429/
https://ncbi.nlm.nih.gov/pubmed/28134751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9020049
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