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Active Site Binding is not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase
The minimal requirements for substrate recognition and turnover by iodotyrosine deiodinase were examined to learn the basis for its catalytic specificity. This enzyme is crucial for iodide homeostasis and the generation of thyroid hormone in chordates. 2-Iodophenol binds only very weakly to the huma...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5330855/ https://ncbi.nlm.nih.gov/pubmed/28157283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01308 |
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