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Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance

Autoimmune responses to meiotic germ cell antigens (MGCA) that are expressed on sperm and testis occur in human infertility and after vasectomy. Many MGCA are also expressed as cancer/testis antigens (CTA) in human cancers, but the tolerance status of MGCA has not been investigated. MGCA are conside...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Tung, Kenneth S.K., Harakal, Jessica, Qiao, Hui, Rival, Claudia, Li, Jonathan C.H., Paul, Alberta G.A., Wheeler, Karen, Pramoonjago, Patcharin, Grafer, Constance M., Sun, Wei, Sampson, Robert D., Wong, Elissa W.P., Reddi, Prabhakara P., Deshmukh, Umesh S., Hardy, Daniel M., Tang, Huanghui, Cheng, C. Yan, Goldberg, Erwin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330742/
https://ncbi.nlm.nih.gov/pubmed/28218625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89927
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