Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance

Autoimmune responses to meiotic germ cell antigens (MGCA) that are expressed on sperm and testis occur in human infertility and after vasectomy. Many MGCA are also expressed as cancer/testis antigens (CTA) in human cancers, but the tolerance status of MGCA has not been investigated. MGCA are conside...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Tung, Kenneth S.K., Harakal, Jessica, Qiao, Hui, Rival, Claudia, Li, Jonathan C.H., Paul, Alberta G.A., Wheeler, Karen, Pramoonjago, Patcharin, Grafer, Constance M., Sun, Wei, Sampson, Robert D., Wong, Elissa W.P., Reddi, Prabhakara P., Deshmukh, Umesh S., Hardy, Daniel M., Tang, Huanghui, Cheng, C. Yan, Goldberg, Erwin
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330742/
https://ncbi.nlm.nih.gov/pubmed/28218625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89927
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