Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness

It has been suggested that compounds affecting glycosylphosphatidylinositol (GPI) biosynthesis in bloodstream form Trypanosoma brucei should be trypanocidal. We describe cell-permeable analogues of a GPI intermediate that are toxic to this parasite but not to human cells. These analogues are metabol...

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Argitaratua izan da:	EMBO J
Egile Nagusiak:	Smith, Terry K, Crossman, Arthur, Brimacombe, John S, Ferguson, Michael A J
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Publishing Group 2004
Gaiak:	Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC533043/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15526036/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600456
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