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Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness
It has been suggested that compounds affecting glycosylphosphatidylinositol (GPI) biosynthesis in bloodstream form Trypanosoma brucei should be trypanocidal. We describe cell-permeable analogues of a GPI intermediate that are toxic to this parasite but not to human cells. These analogues are metabol...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC533043/ https://ncbi.nlm.nih.gov/pubmed/15526036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600456 |
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