Dual Shp2 and Pten Deficiencies Promote Non-Alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells

The complexity of liver tumorigenesis is underscored by the recently observed anti-oncogenic effects of oncoproteins, although the mechanisms are unclear. Shp2/Ptpn11 is a proto-oncogene in hematopoietic cells, and antagonizes the effect of tumor suppressor Pten in leukemogenesis. In contrast, we sh...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Luo, Xiaolin, Liao, Rui, Hanley, Kaisa L., Zhu, Helen He, Malo, Kirsten N., Hernandez, Carolyn, Wei, Xufu, Varki, Nissi M., Alderson, Nazilla, Chu, Catherine, Li, Shuangwei, Fan, Jia, Loomba, Rohit, Qiu, Shuang-Jian, Feng, Gen-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330282/
https://ncbi.nlm.nih.gov/pubmed/27974211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.048
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