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Recombinant expression of Intrepicalcin from the scorpion Vaejovis intrepidus and its effect on skeletal ryanodine receptors

BACKGROUND: Scorpion venoms contain toxins that modulate ionic channels, among which are the calcins, a small group of short, basic peptides with an Inhibitor Cystine Knot (ICK) motif that target calcium release channels/ryanodine receptors (RyRs) with high affinity and selectivity. Here we describe...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Vargas-Jaimes, Leonel, Xiao, Liang, Zhang, Jing, Possani, Lourival D., Valdivia, Héctor H., Quintero-Hernández, Verónica
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5329131/
https://ncbi.nlm.nih.gov/pubmed/28159581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.01.032
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