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Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung

INTRODUCTION: Azithromycin (AZM) reduces pulmonary inflammation and exacerbations in patients with COPD having emphysema. The antimicrobial effects of AZM on the lower airway microbiome are not known and may contribute to its beneficial effects. Here we tested whether AZM treatment affects the lung...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Segal, Leopoldo N, Clemente, Jose C, Wu, Benjamin G, Wikoff, William R, Gao, Zhan, Li, Yonghua, Ko, Jane P, Rom, William N, Blaser, Martin J, Weiden, Michael D
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5329050/
https://ncbi.nlm.nih.gov/pubmed/27486204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2016-208599
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