Local Delivery of the Toll-Like Receptor 9 Ligand CpG Downregulates Host Immune and Inflammatory Responses, Ameliorating Established Leishmania (Viannia) panamensis Chronic Infection

Infection by Leishmania (Viannia) panamensis, the predominant etiologic agent for cutaneous leishmaniasis in Colombia, is characterized by a chronic mixed inflammatory response. Current treatment options are plagued by toxicity, lengthy treatment regimens, and growing evidence of drug resistance. Im...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Ehrlich, Allison K., Fernández, Olga L., Rodriguez-Pinto, Daniel, Castilho, Tiago M., Corral Caridad, Maria J., Goldsmith-Pestana, Karen, Saravia, Nancy Gore, McMahon-Pratt, Diane
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
Assuntos:
Fungal and Parasitic Infections
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328479/
https://ncbi.nlm.nih.gov/pubmed/28052994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00981-16
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