The Sin3a/HDAC corepressor complex functionally cooperates with Nanog to promote pluripotency

Although Sin3a is required for survival of early embryos and embryonic stem cells (ESCs), the role of Sin3a in the maintenance and establishment of pluripotency remains unclear. Here we find that the Sin3a/HDAC corepressor complex maintains ESC pluripotency and promotes the generation of induced plu...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Saunders, Arven, Huang, Xin, Fidalgo, Miguel, Reimer, Michael H., Faiola, Francesco, Ding, Junjun, Sánchez-Priego, Carlos, Guallar, Diana, Sáenz, Carmen, Li, Dan, Wang, Jianlong
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328122/
https://ncbi.nlm.nih.gov/pubmed/28199843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.055
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