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The complicated relationship between Gaucher disease and Parkinsonism: Insights from a rare disease

The discovery of a link between mutations in GBA1, encoding the lysosomal enzyme glucocerebrosidase, and the synucleinopathies directly resulted from the clinical recognition of patients with Gaucher disease with parkinsonism. Mutations in GBA1 are now the most common known genetic risk factor for s...

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Publicat a:Neuron
Autors principals: Aflaki, Elma, Westbroek, Wendy, Sidransky, Ellen
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5327952/
https://ncbi.nlm.nih.gov/pubmed/28231462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.01.018
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