Pharmaceutical characterization of novel tenofovir liposomal formulations for enhanced oral drug delivery: in vitro pharmaceutics and Caco-2 permeability investigations

Tenofovir, currently marketed as the prodrug tenofovir disoproxil fumarate, is used clinically to treat patients with HIV/AIDS. The oral bioavailability of tenofovir is relatively low, limiting its clinical effectiveness. Encapsulation of tenofovir within modified long-circulating liposomes would de...

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Detalles Bibliográficos
Publicado en:Clin Pharmacol
Autores principales: Spinks, Crystal B, Zidan, Ahmed S, Khan, Mansoor A, Habib, Muhammad J, Faustino, Patrick J
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5327912/
https://ncbi.nlm.nih.gov/pubmed/28260952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S119875
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