Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway

An excess of glucocorticoids (GCs) is reported to be one of the most common causes of osteonecrosis of the femoral head (ONFH). In addition, GCs can induce bone cell apoptosis through modulating endoplasmic reticulum (ER) stress. Among the three main signal pathways in ER stress, the PERK (protein k...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Tao, Shi-Cong, Yuan, Ting, Rui, Bi-Yu, Zhu, Zhen-Zhong, Guo, Shang-Chun, Zhang, Chang-Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5327646/
https://ncbi.nlm.nih.gov/pubmed/28255363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.17450
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