Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

WISP2 is a novel adipokine, most highly expressed in the adipose tissue and primarily in undifferentiated mesenchymal cells. As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling and, as an intracellular protein, it helps to maintain precursor cells undifferentiate...

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Pubblicato in:Sci Rep
Autori principali: Grünberg, John R., Hoffmann, Jenny M., Hedjazifar, Shahram, Nerstedt, Annika, Jenndahl, Lachmi, Elvin, Johannes, Castellot, John, Wei, Lan, Movérare-Skrtic, Sofia, Ohlsson, Claes, Holm, Louise Mannerås, Bäckhed, Fredrik, Syed, Ismail, Bosch, Fatima, Saghatelian, Alan, Kahn, Barbara B., Hammarstedt, Ann, Smith, Ulf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5327486/
https://ncbi.nlm.nih.gov/pubmed/28240264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43515
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