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Two unrelated undervirilized 46,XY males with inherited NR5A1 variants identified by whole exome sequencing

BACKGROUND: Undervirilized 46,XY males with bifid scrotum often pose a diagnostic challenge, and the majority of cases typically do not receive a genetic diagnosis. NR5A1 mutations can be seen in 10–20% of cases and are a relatively common cause of undervirilization. METHODS: Whole-exome sequencing...

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Detalhes bibliográficos
Publicado no:Horm Res Paediatr
Main Authors: Swartz, Jonathan M, Ciarlo, Ryan, Guo, Michael H, Abrha, Aser, Diamond, David A, Chan, Yee-Ming, Hirschhorn, Joel N
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325809/
https://ncbi.nlm.nih.gov/pubmed/27553487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000448754
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