Axonal endoplasmic reticulum Ca(2+) content controls release probability in CNS nerve terminals

Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is poorly understood. We developed novel genetically-encoded ER-targeted lowaffinity Ca(2+) indicators optimized for examining axona...

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Bibliographic Details
Published in:Neuron
Main Authors: de Juan-Sanz, Jaime, Holt, Graham T., Schreiter, Eric R., de Juan, Fernando, Kim, Douglas S., Ryan, Timothy A.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325711/
https://ncbi.nlm.nih.gov/pubmed/28162809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.01.010
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