Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis

Cholesterol deposits and pro-inflammatory cytokines play an essential role in the pathogenesis of atherosclerosis, a predominant cause of cardiovascular disease (CVD). Epidemiological evidence has linked periodontal disease (PD) with atherosclerotic CVD. Accordingly, viable periodontal pathogens, in...

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Publicat a:PLoS One
Autors principals: Køllgaard, Tania, Enevold, Christian, Bendtzen, Klaus, Hansen, Peter R., Givskov, Michael, Holmstrup, Palle, Nielsen, Claus H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325525/
https://ncbi.nlm.nih.gov/pubmed/28235036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172773
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