The deubiquitinating enzyme, ubiquitin‐specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein

NOD‐like receptor family protein 3 (NLRP3)‐mediated inflammasome activation promotes caspase‐1‐dependent production of interleukin‐1β (IL‐1β) and requires the adaptor protein ASC. Compared with the priming and activation mechanisms of the inflammasome signaling pathway, post‐translational ubiquitina...

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Bibliographic Details
Published in:FEBS Lett
Main Authors: Lee, Jae Young, Seo, Dongyeob, You, Jiyeon, Chung, Sehee, Park, Jin Seok, Lee, Ji‐Hyung, Jung, Su Myung, Lee, Youn Sook, Park, Seok Hee
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Research Letters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324553/
https://ncbi.nlm.nih.gov/pubmed/28094437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12558
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