Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin

BACKGROUND: Cisplatin is a potent antitumor agent. However, toxicity and primary and secondary resistance are major limitations of cisplatin-based chemotherapy, leading to therapeutic failure. We have previously reported that mono-sulfonamide platinum complexes have good antitumor activity against d...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Agudo-López, Alba, Prieto-García, Elena, Alemán, José, Pérez, Carlos, Díaz-García, C. Vanesa, Parrilla-Rubio, Lucía, Cabrera, Silvia, Navarro-Ranninger, Carmen, Cortés-Funes, Hernán, López-Martín, José A., Agulló-Ortuño, M. Teresa
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324334/
https://ncbi.nlm.nih.gov/pubmed/28231799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0618-7
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