Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death

Constitutively active NFκB promotes survival of many cancers, especially T-cell lymphomas and leukemias by upregulating antiapoptotic proteins such as inhibitors of apoptosis (IAPs) and FLICE-like inhibitory proteins (cFLIPs). IAPs and cFLIPs negatively regulate the ripoptosome, which mediates cell...

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Publicado en:Sci Rep
Autores principales: Schroeder, Anne, Warnken, Uwe, Röth, Daniel, Klika, Karel D., Vobis, Diana, Barnert, Andrea, Bujupi, Fatmire, Oberacker, Tina, Schnölzer, Martina, Nicolay, Jan P., Krammer, Peter H., Gülow, Karsten
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324128/
https://ncbi.nlm.nih.gov/pubmed/28233787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43168
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