Identification of novel inhibitors of the amino acid transporter B(0)AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes

BACKGROUND AND PURPOSE: The neutral amino acid transporter B(0)AT1 (SLC6A19) has recently been identified as a possible target to treat type 2 diabetes and related disorders. B(0)AT1 mediates the Na(+)‐dependent uptake of all neutral amino acids. For surface expression and catalytic activity, B(0)AT...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Cheng, Qi, Shah, Nishank, Bröer, Angelika, Fairweather, Stephen, Jiang, Yang, Schmoll, Dieter, Corry, Ben, Bröer, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323516/
https://ncbi.nlm.nih.gov/pubmed/28176326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13711
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