Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production

Low oxygen concentrations (hypoxia) are known to affect the cellular metabolism and have been suggested to regulate a subpopulation of cancer cells with tumorigenic properties, the so-called tumor-initiating cells (TICs). To better understand the mechanism of hypoxia-induced TIC activation, we set o...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Ullmann, Pit, Qureshi-Baig, Komal, Rodriguez, Fabien, Ginolhac, Aurélien, Nonnenmacher, Yannic, Ternes, Dominik, Weiler, Jil, Gäbler, Karoline, Bahlawane, Christelle, Hiller, Karsten, Haan, Serge, Letellier, Elisabeth
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323168/
https://ncbi.nlm.nih.gov/pubmed/27589845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11772
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