Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis

Angiogenesis is important for tumor growth and metastasis. Hypoxia in tumors drives this angiogenic response by stabilizing Hypoxia Inducible Factors (HIF) and target genes like Vascular Endothelial Growth Factor (VEGF). HIF stability is regulated by Prolylhydroxylases (PHD)-mediated modification. I...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Kir, Devika, Saluja, Manju, Modi, Shrey, Venkatachalam, Annapoorna, Schnettler, Erica, Roy, Sabita, Ramakrishnan, Sundaram
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323160/
https://ncbi.nlm.nih.gov/pubmed/27589831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11689
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