HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy

HuR is an mRNA-binding protein whose overexpression in cancer cells has been associated with poor prognosis and resistance to therapy. While reports on HuR overexpression contributing to chemoresistance exist, limited information is available on HuR and radioresistance especially in triple-negative...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Mehta, Meghna, Basalingappa, Kanthesh, Griffith, James N., Andrade, Daniel, Babu, Anish, Amreddy, Narsireddy, Muralidharan, Ranganayaki, Gorospe, Myriam, Herman, Terence, Ding, Wei-Qun, Ramesh, Rajagopal, Munshi, Anupama
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323119/
https://ncbi.nlm.nih.gov/pubmed/27588488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11706
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