Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis

BACKGROUND: High concentrations of methylglyoxal (MGO) cause cytotoxiticy via formation of advanced glycation endproducts (AGEs) and inflammation. MGO is detoxificated enzymatically by glyoxalase-I (Glo-I). The aim of this study was to analyze the role of Glo-I during the development of cirrhosis. M...

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Vydáno v:PLoS One
Hlavní autoři: Hollenbach, Marcus, Thonig, Antje, Pohl, Sabine, Ripoll, Cristina, Michel, Maurice, Zipprich, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322979/
https://ncbi.nlm.nih.gov/pubmed/28231326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171260
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